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KMID : 0357920010350060524
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Korean Journal of Pathology
2001 Volume.35 No. 6 p.524 ~ p.530
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Expressions and Diagnostic Usefulness of MIB-1 and p53 in Uterine Smooth Muscle Tumors
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Kim Mi-Jin
Kim Yong-Jin
Lee Seung-Ho
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Abstract
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Background: Controversy still remains concerning the criteria for the categorization of uterine smooth muscle tumors by conventional histologic examination. Various ancillary techniques have been used to improve diagnostic accuracy.
Methods: Immunohistochemical study of MIB-1 and p53 was performed on 10 usual leiomyomas (UL), 13 cellular leiomyomas (CL), 5 bizarre leiomyomas (BL), 2 cases of intravenous leiomyomatosis (IL), 5 smooth muscle tumors of uncertain malignant potential (STUMP) and 8 leiomyosarcomas (LMS), to investigate the diagnostic value of MIB-1 and p53 in uterine smooth muscle tumors.
Results: The MIB-1 labelling index was low in ULs and their variants (mean 5.67±5.53), but it was increased in STUMPs (17.67±6.51) and markedly increased in LMSs (35.71±11.35). In ULs and their variants, no immunostaining for p53 was noted except in one case of BL, while 2 (40%) of 5 STUMPs and 3 (38%) of 8 LMSs showed positive reactions for p53. There were significant differences among leiomyoma, STUMP and LMS in the MIB-1 labelling index and p53 expression.
Conclusions: These results suggest that both abnormal expressions of p53 and a high MIB-1 labelling index are frequently associated with leiomyosarcoma. Our data also indicate that the classification system of Kempson and Hendrickson is well correlated with the MIB-1 labelling index.
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KEYWORD
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Uterine neoplasms, Smooth muscle tumor, Protein p53, Ki-67 antigen, Immunohistochemistry
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